Megafen 20 tablets

Tradename:

Megafen

Megafen

Compound:

Each tablet contains:

Ibuprofen 200 mg

Paracetamol 325 mg

Properties:

Combined drug, the action of which is due to its constituent components.

Ibuprofen – NSAIDs, has analgesic, anti-inflammatory, antipyretic effect. By inhibiting COX-1 and COX-2, it disrupts the metabolism of arachidonic acid, reduces the amount of prostaglandins (mediators of pain, inflammation and hyperthermia), both in the focus of inflammation and in healthy tissues, and suppresses the exudative and proliferative phases of inflammation.

Paracetamol – indiscriminately blocks COX, mainly in the central nervous system, has little effect on water-salt metabolism and the gastrointestinal mucosa. It has an analgesic and antipyretic effect. In inflamed tissues, peroxidases neutralize the effect of paracetamol on COX-1 and COX-2, which explains the low anti-inflammatory effect.

The effectiveness of the combination is higher than the individual components. Weakens arthralgia at rest and during movement, reduces morning stiffness and swelling of the joints, increases range of motion.

Indications:

– symptomatic therapy of infectious and inflammatory diseases (colds, flu), accompanied by fever, chills, headache, muscle and joint pain, sore throat;

– myalgia;

-neuralgia;

-back pain;

– articular pain, pain syndrome in inflammatory and degenerative diseases of the musculoskeletal system;

– pain with bruises, sprains, dislocations, fractures;

– post-traumatic and postoperative pain syndrome;

-toothache;

-algodysmenorrhea.

The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use, does not affect the progression of the disease.

Dosage and administration:

Adults and children over 12 years of age:

1 tablet 3 times a day with meals.

Children 6-12 years old: 0.5 tablets 3 times a day with meals.

Contraindications:

– peptic ulcer of the stomach and duodenum in the acute phase;

– gastrointestinal bleeding;

– severe renal failure (CC less than 30 ml / min);

– complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including history);

– damage to the optic nerve;

-genetic absence of glucose-6-phosphate dehydrogenase;

– diseases of the blood system;

– the period after coronary artery bypass grafting.

Precautionary measures:

The simultaneous use of the drug with other drugs containing paracetamol and / or NSAIDs should be avoided. When using the drug for more than 5-7 days, as directed by a doctor, peripheral blood parameters and the functional state of the liver should be monitored.

With the simultaneous use of indirect anticoagulants, it is necessary to monitor the parameters of the blood coagulation system.

Side effects:

From the digestive system: NSAID-gastropathy – nausea, vomiting, heartburn, anorexia, epigastric discomfort or pain, diarrhea, flatulence;

From the nervous system and sensory organs: headache, dizziness, insomnia;

From the side of the cardiovascular system: heart failure, increased blood pressure, tachycardia.

On the part of the hematopoietic organs: anemia (including hemolytic and aplastic), thrombocytopenia, thrombocytopenic purpura, agranulocytosis, leukopenia.

From the respiratory system: shortness of breath, bronchospasm.

Storage method:

Store at a temperature not exceeding 25 degrees.

Package:

The cardboard box contains 1-2 blisters of 10 tablets.