Xanthistop 80 mg 30 tablets

Xanthistop 80 mg 30 tablets

Compound:

Each tablet contains:
Febuxostat 80 mg.

Properties:

• Selective non-purine xanthine oxidase inhibitor, 2-aryl triazole derivative.
• The enzyme xanthine oxidase catalyzes two steps of purine metabolism: the oxidation of hypoxanthine to xanthine and then the oxidation of xanthine to uric acid.
• As a result of selective inhibition of xanthine oxidase (oxidized and reduced forms) by febuxostat, a decrease in the concentration of uric acid in the blood serum occurs.
• The in vitro inhibition constant is less than 1 nM.

Indications:

Treatment of chronic hyperuricemia in conditions accompanied by the deposition of urate crystals (in the presence of tophi and / or gouty arthritis, including a history).
Treatment and prevention of hyperuricemia in adult patients during cytostatic therapy of hemoblastoses with a moderate to high risk of developing tumor disintegration syndrome (only for a dose of 120 mg).

Dosage and administration:

• Taken inside.
• The dose is 80-120 mg 1 time / day.
• The duration of treatment is set individually, depending on the indications.
• The goal of treatment is to lower and maintain serum uric acid levels below 6 mg/dL (357 µmol/L).

Contraindications:

Pregnancy, breastfeeding period;
children’s age up to 18 years;
hypersensitivity to febuxostat.

Precautionary measures:

• Febuxostat should only be started after an acute attack of gout has resolved.
• The use of febuxostat can provoke the development of an acute attack of gout due to the release of urate from tissue depots and a subsequent increase in the concentration of uric acid in the blood serum.
• For the prevention of gout attacks, the simultaneous use of NSAIDs or colchicine for at least 6 months is recommended.

Side effects:

• From the nervous system:
  often – headache;
  infrequently – dizziness, paresthesia, hemiparesis, drowsiness, change in taste perception, hypesthesia, hyposmia (weakening of smell).
• From the endocrine system:
  infrequently – an increase in the concentration of TSH in the blood plasma.
• From the side of metabolism:
  often – attacks of gout;
  infrequently – diabetes mellitus, hyperlipidemia.
• From the digestive system:
  often – diarrhea (more often with the simultaneous use of colchicine), nausea;
  infrequently – abdominal pain, bloating.
• From the side of the liver and biliary tract:
  often – a violation of liver function (more often with the simultaneous use of colchicine);
  infrequently – cholelithiasis, increased activity of alkaline phosphatase, LDH in blood plasma; rarely – hepatitis, jaundice, liver damage.
• On the part of the skin and subcutaneous tissues:
  often – a rash (including various types of rashes mentioned below with a lower frequency).
• General reactions:
  often – edema;
  infrequently – increased fatigue, chest pain.

Storage method:

Store at a temperature not exceeding 30 degrees.

Package:

Cardboard box contains 3 blisters of 10 tablets, paper instructions.