Glucolight XR 1000 mg 30 tablets

Trade name:

Glucolight XR Metformin HCL 1000 mg 30 tablets

Composition:

Each tablet contains:

Metformin hydrochloride 1000 mg

Auxiliary components:

Lactose monohydrate, hypromellose E4, magnesium stearate, colloidal silicon dioxide.

Description:

Antidiabetic agent belongs to Biguanide group used in treatment and prevention of type 2 diabetes mellitus and treatment of polycystic ovary syndrome.

Properties:

Oral hypoglycemic agent from the biguanide group (dimethylbiguanide). The mechanism of action of metformin is associated with its ability to suppress gluconeogenesis, as well as the formation of free fatty acids and fat oxidation. Increases the sensitivity of peripheral receptors to insulin and glucose utilization by cells. Metformin does not affect the amount of insulin in the blood, but changes its pharmacodynamics by reducing the ratio of bound to free insulin and increasing the ratio of insulin to proinsulin.

Metformin stimulates glycogen synthesis by acting on glycogen synthetase. Increases the transport capacity of all types of membrane glucose transporters. Delays the absorption of glucose in the intestine.

Indications:

Diabetes mellitus type 2 (non-insulin dependent) with ineffectiveness of diet therapy and exercise, in obese patients: in adults – as monotherapy or in combination with other oral hypoglycemic agents or with insulin; 

in children aged 10 years and older – as monotherapy or in combination with insulin.

Method of administration and dosage:

The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.

It is taken orally, during or after meals.

The dose and frequency of administration depend on the therapy regimen, the patient’s age and the dosage form used.

Start with 500 mg every 12 hours, or 850 mg once a day with meals. The dose can be increased every two weeks to reach the appropriate continuity dose, which is 1500 to 2550 mg per day, taken orally divided every 8 to 12 hours with meals. The dose should not exceed 2550 mg per day.

Contraindications:

Acute or chronic metabolic acidosis, diabetic ketoacidosis, diabetic precoma, and coma; 

renal failure, impaired renal function (CC <60 ml / min); 

dehydration, severe infection, hypoglycemic shock, which can lead to impaired renal function; clinically pronounced symptoms of acute and chronic diseases that can lead to the development of tissue hypoxia (including heart failure, acute myocardial infarction, respiratory failure); 

the use of contrasting iodine-containing substances for intravascular administration (including when performing intravenous urography, intravenous cholangiography, angiography, CT); 

acute alcohol intoxication, chronic alcoholism; 

hypersensitivity to metformin.

Precautionary measures:

Not recommended for use in acute infections, exacerbation of chronic infectious and inflammatory diseases, trauma, acute surgical diseases, the risk of dehydration.

Do not use before surgery and within 2 days after surgery.

During the period of treatment, patients should avoid drinking alcohol because of the risk of developing lactic acidosis.

Side effects:

From the digestive system: possible (usually at the beginning of treatment) nausea, vomiting, diarrhea, flatulence, abdominal discomfort; in isolated cases – impaired liver function indicators, hepatitis (disappear after stopping treatment).

From the side of metabolism: very rarely – lactic acidosis (discontinuation of treatment is required).

From the side of the hematopoietic system: very rarely – impaired absorption of vitamin B12.

Storage method:

 It should be stored at room temperature away from lighting, excessive heat and moisture.

Package:

The carton box contains 3 blisters of 10 tablets, paper instructions.