Epicotil 20 mg 5 suppositories

Epicotil 20 mg 5 suppositories

Compound:

Each rectal suppository contains:

Tenoxicam 20 mg.

Properties:

NSAIDs of the oxicam class. It has a powerful analgesic and anti-inflammatory effect, the antipyretic effect is less pronounced. The mechanism of action is based on the inhibition of the activity of COX-1 and COX-2 isoenzymes, as a result of which the synthesis of prostaglandins in the focus of inflammation, as well as in other tissues of the body, is reduced. In addition, tenoxicam reduces the accumulation of leukocytes in the focus of inflammation. A distinctive feature of tenoxicam is its long duration of action. Its T1 / 2 is 72 hours.

Indications:

Symptomatic treatment as an anti-inflammatory and analgesic agent: rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, articular syndrome with exacerbation of gout, bursitis, tendovaginitis; pain syndrome of low and moderate intensity (arthralgia, myalgia, neuralgia, migraine, toothache and headache, algomenorrhea); pain from injuries, burns. Inflammatory and degenerative diseases of the musculoskeletal system, accompanied by pain, such as sciatica, lumbago, epicondylitis.

Dosage and administration:

Apply rectally. The recommended dose is 20 mg 1 time / day. The duration of the course of treatment is 7-14 days.

Contraindications:

Hypersensitivity to tenoxicam and other NSAIDs; erosive and ulcerative lesions of the gastrointestinal tract (including history), gastrointestinal bleeding (including history), inflammatory diseases of the gastrointestinal tract (Crohn’s disease or ulcerative colitis in the acute phase), severe renal failure (CC less than 30 ml / min), progressive kidney disease, severe liver failure; complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including history); established diagnosis of diseases of the blood coagulation system, decompensated heart failure, treatment of perioperative pain during coronary artery bypass grafting. Pregnancy, lactation (breastfeeding); children and adolescents up to 16 years of age.

Precautionary measures:

When using tenoxicam, you should carefully monitor the function of the gastrointestinal tract. If the first signs of ulcerogenesis or gastrointestinal bleeding are detected, tenoxicam should be immediately discontinued.

Tenoxicam reduces platelet aggregation and increases bleeding time, which should be borne in mind for future surgical interventions.

Side effects:

From the hemopoietic system: often – agranulocytosis, leukopenia.

From the nervous system: often – dizziness, headache, drowsiness, depression, agitation, hearing loss, tinnitus, irritation and swelling of the eyelids, blurred vision.

From the digestive system: very often – dyspepsia (nausea, vomiting, heartburn, diarrhea, flatulence), NSAID-gastropathy, abdominal pain, stomatitis, anorexia, abnormal liver function.

From the skin and subcutaneous tissues: often – itching, rash, urticaria, erythema.

From the urinary system: often – an increase in the content of urea nitrogen and creatinine in the blood plasma.

Storage method:

Store in the refrigerator, at a temperature not higher than 2-8 degrees.

Package:

The cardboard box contains a blister of 5 suppositories, paper instructions.