Dosin 4 mg, 20 tablets

Trade Name:

Dosin

Composition:

Each tablet contains:

Doxazosin mesylate 4 mg

Auxiliary components:

lactose monohydrate (milk sugar), microcrystalline cellulose, sodium carboxymethyl starch, povidone K25, magnesium stearate, sodium lauryl sulfate.

Properties:

Selective competitive blocker of postsynaptic α1-adrenergic receptors. Causes expansion of peripheral vessels, which leads to a decrease in peripheral vascular resistance and a decrease in blood pressure. It helps to increase the HDL / total cholesterol ratio, reduce the total level of triglycerides and cholesterol.

With prolonged use, there is a regression of left ventricular hypertrophy, there is a suppression of platelet aggregation and an increase in the content of plasminogen activator in the tissues. Blockade of α1-adrenergic receptors located in the stroma and capsule of the prostate gland in the bladder neck leads to a decrease in resistance and pressure in the urethra, a decrease in resistance in its internal opening. Improves urodynamics and reduces the manifestations of benign prostatic hyperplasia (BPH).

Indications:

Benign prostatic hyperplasia (BPH); arterial hypertension (including symptomatic) as part of combination therapy.

Dosage and administration:

inside. The dose and regimen are determined individually, depending on the indications and the clinical situation.

For BPH, the recommended starting dose is 1 mg/day. Depending on the clinical situation, the dose may be increased to achieve the optimal therapeutic effect. The average daily dose is 2-4 mg. The maximum daily dose is 8 mg.With arterial hypertension, the dose varies from 1 to 16 mg / day. Treatment is recommended to start with a dose of 1 mg 1 time / day. To achieve the desired reduction in blood pressure, if necessary, the daily dose should be increased gradually, observing uniform intervals up to 4 mg, 8 mg and up to a maximum of 16 mg, depending on the severity of the patient’s response to doxazosin. The average daily dose is 2-4 mg.

Contraindications:

Hypersensitivity to doxazosin and other quinazoline derivatives; severe liver failure (in the absence of experience in this category of patients); urinary tract infections; anuria; progressive renal failure; arterial hypotension and a tendency to orthostatic disorders (including history); concomitant obstruction of the upper urinary tract; bladder stones; urinary incontinence due to overfilling of the bladder (paradoxical ischuria); children and adolescents up to 18 years of age.With caution: pulmonary edema caused by mitral valve stenosis or aortic stenosis; heart failure with increased cardiac output; right ventricular failure due to pulmonary embolism or exudative pericarditis; left ventricular failure with low filling pressure; disorders of cerebral circulation; age over 65 due to the risk of developing orthostatic symptoms (fainting, dizziness); simultaneous use with inhibitors of phosphodiesterase type 5 (PDE-5) (the threat of symptomatic arterial hypotension); liver dysfunction; pregnancy; during cataract surgery.

Warnings and precautions:

After taking doxazosin at the initial dose, orthostatic hypotension (the phenomenon of the first dose) may develop, especially in the standing position. More often this condition is observed in patients with hypovolemia, sodium deficiency, in the elderly. In this regard, the initial dose is recommended to be taken at bedtime. Doxazosin should be used with caution in elderly patients due to the possibility of orthostatic hypotension. With age, the risk of dizziness, visual impairment and fainting increases.

The patient should be informed of the increased risk of developing orthostatic hypotension with alcohol, prolonged standing or exercise, and hot weather.

In patients with BPH, doxazosin can be prescribed both in the presence of arterial hypertension and in normal blood pressure.When used in patients with BPH with normal blood pressure, the change in the latter is not significant. At the same time, in patients with a combination of arterial hypertension and BPH, it is possible to use it in monotherapy.

Side effects:

On the part of the psyche: often – agitation, anxiety, insomnia; infrequently – depression.

From the nervous system: very often – dizziness, headache; often – paresthesia, postural dizziness (after taking the first dose, a pronounced decrease in blood pressure is possible, which can lead to orthostatic dizziness, in severe cases, especially when moving quickly from a lying position to a standing position or to a sitting position – to fainting ), drowsiness; infrequently – hypesthesia, fainting, tremor.

Infectious and parasitic diseases: often – respiratory tract infections, urinary tract infections.

On the part of the organ of vision: often – a violation of color perception; infrequently – atonic iris syndrome.

On the part of the organ of hearing and labyrinth disorders: often – vertigo; infrequently – tinnitus.

From the side of the cardiovascular system: often – tachycardia; infrequently – flushing of blood to the skin of the face, a pronounced decrease in blood pressure, postural hypotension; rarely – angina pectoris, myocardial infarction, cardiac arrhythmias; very rarely – bradycardia, arterial hypertension.

From the respiratory system: often – shortness of breath, rhinitis; infrequently – cough, nosebleeds; very rarely – exacerbation of existing bronchospasm.

From the digestive system: often – nausea, abdominal pain, diarrhea, dyspepsia, dryness of the oral mucosa; infrequently – flatulence, constipation, gastroenteritis, vomiting; frequency is unknown – a violation of taste.

From the side of the liver and biliary tract: very rarely – cholestasis, hepatitis, jaundice, increased activity of liver transaminases.

Storage:

At a temperature not exceeding  30°C in a dry place. 

Package:

Carton box contains 2 blisters of 10 tablets.