Sugarlo Plus 50/850 mg 30 tablets

Sugarlo Plus 50/850 mg 30 tablets


Composition:

Each tablet contains:

Vildagliptin 50 mg

Metformin hydrochloride 850 mg.

Description:

Combined oral antidiabetic agent containing vildagliptin (DPP-4 inhibitor) and metformin (biguanide). Used for blood glucose control in type 2 diabetes mellitus when metformin monotherapy or combination with other agents is insufficient.

Indications:

- Type 2 diabetes mellitus in adults:

- Combined with diet and exercise.

- As add-on to sulfonylurea or insulin when glycemic control is inadequate.

Dosage and Administration:

Standard dose: 1 tablet twice daily with meals.

Dose adjustment: Based on renal function and concomitant therapy.

Renal impairment: Dose adjustment required (contraindicated if Cl cr < 60 mL/min).

Elderly: Dose adjustment based on renal function.

Important:

Swallow whole with water, do not chew.

Do not exceed maximum daily dose: 100 mg vildagliptin / 2000 mg metformin.

Contraindications:

- Hypersensitivity to vildagliptin, metformin, or excipients.

- Severe renal impairment (Cl cr < 60 mL/min).

- Diabetic ketoacidosis, type 1 diabetes.

- Heart failure, recent myocardial infarction.

- Severe infections, dehydration, alcoholism.

- Pregnancy, lactation.

- Children under 18 years.

Precautions:

Before treatment:

Assess renal and hepatic function.

Test glucose, HbA1c, vitamin B12 levels.

During treatment:

Regular liver function monitoring (every 3 months in first year).

Renal function monitoring (annually, more frequently in elderly).

Vitamin B12 levels (every 2–3 years).

During radiocontrast procedures:

Discontinue 48 hours before and resume 48 hours after the procedure.

Adverse Effects:

Common (>1/100):

Dizziness, nausea, diarrhea, abdominal pain.

Hypoglycemia (when combined with sulfonylurea or insulin).

Rare (<1/1000):

Allergic reactions (angioedema, rash).

Liver dysfunction (elevated ALT, AST).

Lactic acidosis (rare but life-threatening).

Symptoms of lactic acidosis:

Muscle pain, weakness, difficulty breathing, nausea, vomiting.

Requires immediate medical attention!

Pregnancy and Lactation:

Pregnancy: Contraindicated. Use insulin.

Lactation: Not recommended (no data on excretion in milk).

Storage:

Store below 30°C in a dry place.

Package:

Carton box containing 1–3 blisters (10 tablets each) + leaflet.